gp130 receptor cytokines stat3 depicting hypertrophy ras bind signaling binding ligand stat phosphorylation pathways pi3k raf proteins subunits cytoplasmic phosphorylated
gp130 osm signaling receptor stat3 response mapk pi3k
gp130 signalling tyrosine representation distinct schematic residues shp ras erk
signaling cis expression cellular receptor gp130 either activates erk stat3 vegf soluble pathways promote
graphical targeting liver gp130 jak1 mirnas stat3 modulation signaling pathway
gp130 il transducer sequentially activation receptor induced cooperate signal epitopes different two figure jimmunol
transducer maintenance vitro signal experimentally evidence induced vivo expressed genetic induction hypersensitivity mechanical gp130 essential role il