gp130 receptor cytokines stat3 depicting hypertrophy ras bind signaling binding ligand stat phosphorylation pathways pi3k raf proteins subunits cytoplasmic phosphorylated
cytokine signaling pathways tumor important
cytokine transduction signal jak stat pathway schematic activation binding receptors kinases receptor cytokines bind kinase proteins
cytokine stat receptor pathway signaling socs receptors cytokines
graphical abstract distinct cytokines molecular receptor mechanisms signal shared through il use family their
ifn signaling receptor ifns response isre irf expression stimulated stat2 stat1 isgs genes nucleus antiviral
signal mechanisms downstream cytokines transduction family gp130 cytokine therapeutic glycoprotein cardiovascular diseases stimulation