cancer cell keap1 drug binding antioxidative competing nrf2 resistance drives factor growth res hi
homology hiti crispr targeted sgrna gene donor repair cleaves flanking pathways nhej plasmid genome publication inserted deletions repaired dsbs genomic
repressors engineered transcriptional screening
keap1 domains characteristic btb ivr kelch brac bric
exosome delivery engineered rna exosomes targeted using therapeutic targeting
sgrna cas9 schematic binary gene crispr scaffold binding
action cancer oncolytic viruses mechanisms review virus tumor targeting ov niche advances key cells figure engineered ol least seven grow